Morphea-like reaction to D-penicillamine therapy.
نویسندگان
چکیده
منابع مشابه
Morphea-like reaction to D-penicillamine therapy.
We report the case of a 48-year-old woman who developed morphea-like plaques after 1 year of treatment with D-penicillamine at 250 mg daily for a seronegative erosive arthritis of rheumatoid type. The rash began as several red itchy patches on the trunk; these became thickened and shiny over about 3 months. The histological appearance was of increased dermal fibrosis with an inflammatory infilt...
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Cross-sectional and longitudinal studies have been carried out to determine the incidence and clinical significance of eosinophilia in patients taking penicillamine for rheumatoid arthritis. In a cross-sectional study of 204 patients eosinophilia was found with equal frequency during treatment with penicillamine, gold, and nonsteroidal anti-inflammatory drugs. A longitudinal study of 89 patient...
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Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases of solubilized arsenic trioxide poisoning in Navajo Indian children and one case of sodium arsenate ingestion in an infant. One fatality occurred during dimercaprol therapy prior to initiation of therapy with D-penicillamine. Th...
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Red cell aplasia developed in a case of Wilson's disease following an increase in D-penicillamine dosage after 14 years' treatment. In vitro study of the effect of D-penicillamine on 59Fe incorporation by marrow cells did not suggest that the patient's erythropoiesis was particularly sensitive to D-penicillamine or determine the mechanism of drug toxicity. However, three weeks after the drug wa...
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A patient with sero-positive rheumatoid arthritis was treated with D-penicillamine (cumulative dose 3 . 7 3 9 . Three weeks after starting therapy she developed a fever, rash and a cholestatic jaundice. Cessation of D-penicillamine resulted in improvement. However, reintroduction of D-penicillamine 1 0 days later (cumulative dose 2g), was followed by acute hepatic failure and death. Liver biops...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1981
ISSN: 0003-4967
DOI: 10.1136/ard.40.1.42